It rises over the site of a smaller church, dedicated to the same saint who, according to tradition, was a guest of the matron Paola here. In 1524, Clement VII assigned it to the Company of Charity, formed by him for the purposes of helping the poor. The interior has a single nave with two chapels on each side and another two on either side of the high altar. In the first chapel on the right, belonging to the Spada family since 1595, is entered through a baroque device, moving, that is, the wings of the angel on the left.

LittIe is known of the early works, buI those begun in 1654 are documented through the interest of father Virgilio Spada, a close friend of the architect, even after the close collaboration in the Vallicelli complex.The question of whether the decoration of the chapel was by Borromini or not is controversial; it is probable that the architect and the religious man were both concerned, even if the work is a long way from the later style of Borromini. 

The chapel is rectangular and the walls are completely covered in polychroma marble creating a special scenic and picturesque effect; the veining of the stone, in fact, resemble a damask cloth. On the rich surfaces marble tondos with profiles, in relief, of the more important personalities of the family. The two large sepulchres on the sidewalls complete the decoration. Statues of the two members of the family are placed above them, the work of students of Gianlorenzo Bernini.